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HIF-1α Mouse anti-Human, Unlabeled, Clone: 54, BD

Mouse Monoclonal Antibody

$232.00 - $458.00

Specifications

Antigen HIF-1α
Isotype IgG1, κ
Immunogen Human HIF-1α aa. 610-727
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610958
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BD Biosciences
610958
50μg
Each for $232.00
Add to cart
 
BDB610959
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BD Biosciences
610959
150μg
Each for $458.00
Add to cart
 
Description

Description

Molecular oxygen (O2) is essential for mammalian metabolic processes such as oxidative phosphorylation. Thus, survival depends upon instantaneous transcriptional modulation of genes that maintain O2 homeostasis. Transcriptional control of several of these genes is mediated by hypoxia-inducible factor 1 (HIF-1). HIF-1 is a heterodimer whose α and β subunits are members of the PAS family of basic helix-loop-helix (bHLH) transcription factors. Common structural features of these proteins are an N-terminal bHLH DNA-binding domain and multiple PAS domains that confer dimerization ability and target gene specificity. Members diverge in their C-terminal regions. HIF-1β is also known as the arylhydrocarbon nuclear translocator which is part of the functional dioxin receptor. However, HIF-1α functions exclusively to mediate responses to O2 deprivation. It contains C-terminal and internal transactivation domains. Although HIF-1 aproteinlevels increase during hypoxia, it is unstable in the presence of O2 due to an oxygen-dependent degradation domain (ODD) that targets it for ubiquitination. Thus, HIF-1α is essential for functional HIF-1 to mediate gene transcription in response to hypoxia.

Immunofluorescence, Western Blotting

Specifications

Specifications

HIF-1α
Human HIF-1α aa. 610-727
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
MOP1
IgG1, κ
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
54
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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