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IL-1 alpha Rat anti-Mouse, Clone: 40508, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523828

Catalog No. PIMA523828


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Description

Description

In ELISAs, this antibody shows less than 1% cross-reactivity with recombit rat (rr) IL-1 alpha /IL-1F1, rpIL-1 alpha /IL-1F1, or rhIL-1 alpha /IL-1F1. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Specifications

Specifications

IL-1 alpha
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P01582
IL-1 alpha, hematopoietin-1, interleukin-1 alpha, preinterleukin 1 alpha, pro-interleukin-1-alpha, Hematopoietin-1, IL1A
Rat
IgG2B
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
16175
ELISA, Neutralization
40508
Unconjugated
Il1a
Lyophilized
IL1A
E. coli-derived recombit mouse IL-1 alpha/IL-1F1 Ser115-Ser270
Protein A/G
RUO
Antibody
Monoclonal
Mouse
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