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Mint1 Mouse, Unlabeled, Clone: 23, BD

Catalog No. BDB611028 Shop All BD Biosciences Products
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BDB611028 50 μg
BDB611029 150 μg
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Catalog No. BDB611028 Supplier BD Biosciences Supplier No. 611028

Description

Mouse Monoclonal Antibody

Neuronal communication via neurotransmitter release is mediated by the synaptic vesicle cycle. The initial step in exocytosis is the docking of the vesicle in the active zone of the plasma membrane. This step is followed by fusion of the vesicle and plasma membrane and exocytosis. Munc18-1, a major brain protein, is essential for exocytosis. It binds the vesicle fusion protein syntaxin, along with Doc2a and 2b, two proteins that associate peripherally with the synaptic vesicle. Munc18-1 is a family member of membrane trafficking proteins. Its function is thought to be mediated by two Munc18-1-interacting proteins termed Mint 1 and Mint 2, which are 50% homologous. They are expressed exclusively in brain and bind Munc18-1 (MID) with high affinity. They contain an N-terminal Munc18-1 interacting domain and C-terminal PTB (pTyr/PIP interaction) and PDZ (membrane protein interaction) domains, suggesting the ability of Mint proteins to link vesicle exocytosis to Tyr phosphorylation and/or localization at synaptic intercellular junctions. Thus, the Mint proteins, along with Munc18-1 and syntaxin, form a multimeric complex that mediates appropriate docking/fusion of synaptic vesicles.

Immunofluorescence, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Mint1
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone 23
Concentration 250μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Rat Mint 1 aa. 268-377
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Mouse, Rabbit, Rat
Isotype IgG1
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For Research Use Only.

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