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Mint1 Mouse, Unlabeled, Clone: 23, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 611028

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Catalog No. BDB611028

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Neuronal communication via neurotransmitter release is mediated by the synaptic vesicle cycle. The initial step in exocytosis is the docking of the vesicle in the active zone of the plasma membrane. This step is followed by fusion of the vesicle and plasma membrane and exocytosis. Munc18-1, a major brain protein, is essential for exocytosis. It binds the vesicle fusion protein syntaxin, along with Doc2a and 2b, two proteins that associate peripherally with the synaptic vesicle. Munc18-1 is a family member of membrane trafficking proteins. Its function is thought to be mediated by two Munc18-1-interacting proteins termed Mint 1 and Mint 2, which are 50% homologous. They are expressed exclusively in brain and bind Munc18-1 (MID) with high affinity. They contain an N-terminal Munc18-1 interacting domain and C-terminal PTB (pTyr/PIP interaction) and PDZ (membrane protein interaction) domains, suggesting the ability of Mint proteins to link vesicle exocytosis to Tyr phosphorylation and/or localization at synaptic intercellular junctions. Thus, the Mint proteins, along with Munc18-1 and syntaxin, form a multimeric complex that mediates appropriate docking/fusion of synaptic vesicles.

Immunofluorescence, Western Blotting



Affinity Purified
Immunofluorescence, Western Blot
Rat Mint 1 aa. 268-377
50 μg
Cell Biology
Mouse, Rabbit, Rat


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