anti-IFN-alpha D, Clone: N27, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP142171
DescriptionIFN-alpha 1 Monoclonal specifically detects IFN-alpha 1 in Human, Mouse, Rat samples. It is validated for Western Blot, ELISA, Immunohistochemistry-Frozen, Block/Neutralize.
|PBS with 0.05% Sodium Azide|
|The antibody reacts with the IFN-Alpha antigen.|
|Cancer, Immunology, Innate Immunity|
|Western Blot, ELISA, Blocking Assay|
|Western Blot 1:100-1:2000, ELISA 1:100-1:2000, Blocking/Neutralizing 50-200 molar excess|
|IFL, IFN, IFNA13, IFNAalphaIFN-alpha-1/13, IFN-ALPHA, IFN-alpha 1b, IFN-alphaD, interferon alpha 1b, interferon alpha-1/13, Interferon alpha-D, interferon, alpha 1, LeIF D, MGC138207, MGC138505, MGC138507|
|Protein A or G purified|
|Store at 4C. Do not freeze.|
|The alpha interferons are involved in virus resistance in target cells for these viruses. They are known to block cell proliferation and to regulate MHC class I antigen expression. The IFNalpha family has pseudogenes in two families (I and II), one with a mature length of 166aa and one of 172aa. Cells producing IFNalpha are lymphocytes, monocytes, macrophages and cell lines such as Namalwa and KGI. Bioassays for IFNalpha include cytopathic effect blocking, by viruses such as VSV, SFV and BMCV, on their target cells. A number of receptors for IFNalpha are now known and seem to be expressed on most cell types. N27 is specific for INFalpha(II) and does not cross react with INFalpha(I). Source: A BALB/c mouse was immunized with E-coli derived, purified recombinant IFN-alpha 2c and spleen cells were fused with mouse myeloma cells NS1.|
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