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MSH6 Mouse, Unlabeled, Clone: 44, BD

Mouse Monoclonal Antibody

$226.00 - $448.00

Specifications

Antigen MSH6
Isotype IgG1
Immunogen Human MSH6 aa. 225-333
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610918
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BD Biosciences
610918
50μg
Each for $226.00
Add to cart
 
BDB610919
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BD Biosciences
610919
150μg
Each for $448.00
Add to cart
 
Description

Description

DNA mismatch repair in bacteria is carried out by the MutL, MutH, and MutS proteins. Initial binding of MutS to the mismatched DNA is followed by binding of the MutH endonuclease and MutL. Together these proteins form a complex that mediates excision repair. Mutations or deficiencies of any of these bacterial proteins results in a mutator phenotype that is characterized by genetic instability. MSH2, MSH3 and MSH6 are human homologs of MutS, while MLH1, PMS1, and PMS2 are homologs of MutL. As a heterodimer with MSH2, MSH6 binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes single-base mispairs and insertion/deletion loops. Binding of this complex induces conformational changes in the DNA that lead to the binding of an MLH-PMS1 complex and excision repair. Mutations in the human genes are associated with hereditary nonpolyposis colon cancer (HNPCC), a common hereditary disease in humans. HNPCC is characterized by frequent microsatellite mutations that arise from somatic mutation due to a replication error (RER+) phenotype. This phenotype is analogous to the bacterial system and is directly linked to DNA mismatch repair deficiencies.

Immunofluorescence, Western Blotting

Specifications

Specifications

MSH6
Human MSH6 aa. 225-333
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
GTBP
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
44
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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