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NCK Mouse, Unlabeled, Clone: 108, BD

Mouse Monoclonal Antibody

$232.00 - $431.00

Specifications

Antigen NCK
Isotype IgG2b
Immunogen Human NCK aa. 279-377
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610100
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BD Biosciences
610100
150μg
Each for $431.00
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BDB610099
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BD Biosciences
610099
50μg
Each for $232.00
Add to cart
 
Description

Description

NCK is a 47kDa protein that belongs to a class of signaling molecules called adaptors. These proteins exert their effects by coupling activated receptors to downstream effectors. NCK is comprised almost entirely of one SH2 and three SH3 domains and it possesses no intrinsic catalytic activity. Investigations of its interactions with cellular proteins have found constitutive association of NCK with various Ser/THr kinases, such as p21-associated kinase (PAK) and casein kinase 1. Other proteins that directly interact with NCK are: Sos, Cbl, Wiskott-Aldrich syndrome protein (WASP), IRS1, and multiple tyrosine kinase receptors. The presence of NCK is necessary for the mitogenic response elicited by PDGF in some cells. In addition, the Drosophila homologue of NCK is involved in regulating cytoskeletal organization.

Host Species: Mouse
Clone: 108
Isotype: IgG2b
Species Reactivity: Human
Immunogen: Human NCK aa. 279-377
Formula Weight [Chemical]: 47kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

NCK
Human NCK aa. 279-377
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG2b
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
108
250μg/mL
SDS
Product Certifications

For Research Use Only.

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