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Neurotensin Receptor 3 (NTR3) Mouse, Unlabeled, Clone: 48, BD

Mouse Monoclonal Antibody

$286.00 - $566.00

Specifications

Antigen Neurotensin Receptor 3 (NTR3)
Clone 48
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB612100
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BD Biosciences
612100
50 μg
Each for $286.00
Only null left
Add to Cart
 
BDB612101
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BD Biosciences
612101
150 μg
Each for $566.00
Only null left
Add to Cart
 
Description

Description

Neurotensin (NT) is a neuropeptide that modulates dopaminergic transmission, triggers analgesic responses, induces hypotension, decreases gastric acid secretion, and activates lipid digestion. NT is a ligand for NT receptors, which include both G-protein coupled and non-G-protein coupled receptors. Neurotensin Receptor 3 (NTR3) is a non-G-protein coupled receptor that has a lumenal domain homologous to sorting proteins, and a short cytoplasmic tail homologous to mannose-6-phosphate/IGF-II receptor. NTR3 was also identified as sortilin/gp95, a component of GLUT4 vesicles in adipocytes that has been implicated in lipoprotein lipase degradation. NTR3 mRNA is expressed in brain, skeletal muscle, heart, and adipocytes. NTR3 mature protein has 44 N-terminal amino acid residues cleaved off, which may facilitate ligand binding to the receptor. Cellular localization of NTR3 is in the Golgi compartment and vesicles, as well as on the cell surface. In addition to roles in neuropeptide and lipoprotein degradation, NTR3 may also be involved in receptor protein sorting. Thus, NTR3 is a multifunctional transmembrane protein that acts as both a intracellular sorting receptor and extracellular ligand-binding receptor.

Immunofluorescence, Western Blotting

Specifications

Specifications

Neurotensin Receptor 3 (NTR3)
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
NTR3
48
Western Blot
Unconjugated
RUO
Canine, Chicken, Human, Mouse, Rat
Human Neurotensin Receptor 3 aa. 300-422
Primary
Store undiluted at -20°C.
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