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NF-κB p65 Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

$226.00 - $421.00

Specifications

Antigen NF-κB p65
Isotype IgG1
Immunogen Human NF-κB aa. 136-224
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610869
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BD Biosciences
610869
150μg
Each for $421.00
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BDB610868
View Documents Promotion Details
BD Biosciences
610868
50μg
Each for $226.00
Add to cart
 
Description

Description

NF-κB is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. The most studied NF-κB complex consists of the p50 and p65 subunits, both containing a 300 amino acid region with homology to the Rel proto-oncogene product. The p50 subunit binds DNA, whereas the p65 subunit is responsible for the interaction of NF-κB with its inhibitor, IκB. In most cell types, the p50/p65 heterodimer is located within the cytoplasm complexed to IκB. This complex prevents nuclear translocation and activity of NF-κB. In response to stimuli such as cytokines, LPS, and viral infections, IκB is phosphorylated at critical residues. This phosphorylation induces dissociation of the IκB/NF-κB complex, allowing the free heterodimeric
NF-κB to form a heterotetramer that translocates to the nucleus. In the nucleus, it binds to the κB site within promoters and enhancers and functions as a transcriptional activator.

Immunofluorescence, Western Blotting

Specifications

Specifications

NF-κB p65
Human NF-κB aa. 136-224
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
20
250μg/mL
SDS
Product Certifications

For Research Use Only.

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