Invitrogen™ NRCAM Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547999

Catalog No. PIPA547999

Description

Reconstitute at 0.2 mg/mL in sterile PBS.

Neuron-glia-related cell adhesion molecule (NRCAM) is a gene located on chromosome 7q31.1, encoding a protein that belongs to the immunoglobulin superfamily of cell adhesion molecules. NRCAM is expressed in the nervous system and plays a vital role in the development and maintenance of neural connections. This adhesion molecule facilitates neuron-neuron and neuron-glia interactions, impacting processes such as axon guidance, synapse formation, and cell signaling, which are crucial for neural development and plasticity. NRCAM is involved in the modulation of signal transduction pathways that influence neuronal growth and repair, contributing to the stabilization of synaptic structures. Alterations in NRCAM expression or function have been linked to neurodevelopmental disorders, including autism spectrum disorders, and certain psychiatric conditions, reflecting its importance in maintaining neural circuit integrity. Research into NRCAM continues to explore its therapeutic potential in neurobiology and its implications in neurological and psychiatric disorders.

Specifications

• Antigen: NRCAM
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NRCAM
• Gene Alias: ankyrin-binding cell adhesion molecule NrCAM; Bravo; C030017F07Rik; C130076O07Rik; hBravo; KIAA0343; mBravo; MGC138845; MGC138846; mKIAA0343; neuronal cell adhesion molecule; Neuronal surface protein Bravo; neuron-glia-CAM-related cell adhesion molecule; ng-CAM-related; NgCAM-related cell adhesion molecule; Nr CAM; Nrcam; nr-CAM; rBravo
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4897
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q92823
• Gene Symbols: NRCAM
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human NrCAM isoform 3 Leu30-Asn600 (Ala526Pro).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG