PCNA Mouse, Unlabeled, Clone: 24, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB610665	BD Biosciences 610665	150μg
BDB610664	BD Biosciences 610664	50μg

Description

Progression of the mammalian cell cycle is regulated in two different ways: 1) phosphorylation and dephosphorylation of key proteins, 2) synthesis and degradation of regulatory factors. The Proliferating Cell Nuclear Antigen (PCNA) was initially identified as a nuclear antigen in proliferating cells and was subsequently described as a subunit for DNA polymerase δ. Human PCNA is 262 amino acids with an apparent molecular weight of 36kDa. PCNA protein levels peak during the S-phase of the cell cycle, at which time it forms a complex with the p21 inhibitor. PCNA is almost undetectable in other phases of the cycle. Because of its unique expression, PCNA has been extensively used in studies associating the prognosis of tumor progression and neoplastic proliferation.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: PCNA
• Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Conjugate: Unconjugated
• Research Discipline: Cell Biology
• Host Species: Mouse
• Format: Affinity Purified
• Monoclonal or Polyclonal: Monoclonal
• Description: Proliferating Cell Nuclear Antigen

• Isotype: IgG₁
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Primary or Secondary: Primary
• Applications: Western Blot
• Regulatory Status: RUO
• Clone: 24
• Concentration: 250μg/mL
• Storage Requirements: Store undiluted at -20°C.

For Research Use Only.