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Pericentrin Mouse anti-Mouse, Unlabeled, Clone: 30, BD

Mouse Monoclonal Antibody

$232.00 - $427.00

Specifications

Antigen Pericentrin
Isotype IgG1
Immunogen Mouse pericentrin aa. 1692-1814
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611814
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BD Biosciences
611814
50μg
Each for $232.00
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BDB611815
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BD Biosciences
611815
150μg
Each for $427.00
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Description

Description

Centrosomes and other microtubule-organizing centers are a diverse group of organelles that nucleate and organize microtubules for many celllular processes, such as mitotic spindle formation, organelle tranpsort, and protein localization. Pericentrin is a protein in the pericentriolar material, a filamentous matrix surrounding centrioles, which can organize microtubule spindle formation. The structure of pericentrin includes multiple α-helical domains that form coiled-coil domains separated by non-helical, non-coiled regions. It is found in a 3MDa-complex that includes γ-tubulin, a form of tubulin that nucleates microtubule formation at the centrosome. Pericentrin exhibits the highest expression in embryonic mouse kidney, thymus, and liver. Injection of pericentrin antibodies in Xenopus oocytes disrupts mitotic and meiotic divisions and blocks microtubule aster formation. In addition, dynein transports both pericentrin and γ-tubulin to centrosomes along microtubules in Xenopus oocyte extracts. Thus, the complex of pericentrin and γ-tubulin may be recruited to the centrosome by dynein, where the complex becomes anchored to the centrosome for microtubule nucleating activity.

Host Species: Mouse
Clone: 30
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Mouse pericentrin aa. 1692-1814

Immunofluorescence, Western Blotting

Specifications

Specifications

Pericentrin
Mouse pericentrin aa. 1692-1814
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
30
250μg/mL
SDS
Product Certifications

For Research Use Only.

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