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PTP1C/SHP1 Mouse, Unlabeled, Clone: 52, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610126

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Catalog No. BDB610126

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PTP1C (SH-PTP1, SHP-1, or HCP) is a protein-tyrosine phosphatase (PTP) that is expressed in epithelial and hematopoietic cells. It contains two N-terminal SH2 domains and a C-terminal phosphatase domain. While its distribution is primarily cytosolic, exposure to various stimuli induces movement of PTP1C to other cellular locations to allow interaction with its substrates. This enzyme associates with the IL-3, IL-4, erythropoietin, and stem cell factor receptors and may regulate their signaling pathways by dephosphorylation of their receptors or their downstream effectors. Motheaten mice, which possess a nonfunctional PTP1C gene, display multiple hematopoietic abnormalities including increased proliferation and activation of myeloid cells. Studies involving these mice have clearly implicated PTP1C in negative regulation of CSF-1 (colony stimulating factor-1) mitogenic signaling and have demonstrated a role for PTP1C as an intermediate between Ras and the MAP kinase pathway.

Host Species: Mouse
Clone: 52
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human PTP1C aa.. 492-597
Formula Weight [Chemical]: 68kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting



Affinity Purified
Human PTP1C aa.. 492-597
Cell Biology
Canine, Human, Murine, Rat
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
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