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PTP1C/SHP1 Mouse, Unlabeled, Clone: 52, BD

Mouse Monoclonal Antibody

$287.50 - $572.00

Specifications

Antigen PTP1C/SHP1
Clone 52
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610125
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BD Biosciences
610125
50 μg
Each for $287.50
Only null left
Add to Cart
 
BDB610126
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BD Biosciences
610126
150 μg
Each for $572.00
Only null left
Add to Cart
 
Description

Description

PTP1C (SH-PTP1, SHP-1, or HCP) is a protein-tyrosine phosphatase (PTP) that is expressed in epithelial and hematopoietic cells. It contains two N-terminal SH2 domains and a C-terminal phosphatase domain. While its distribution is primarily cytosolic, exposure to various stimuli induces movement of PTP1C to other cellular locations to allow interaction with its substrates. This enzyme associates with the IL-3, IL-4, erythropoietin, and stem cell factor receptors and may regulate their signaling pathways by dephosphorylation of their receptors or their downstream effectors. Motheaten mice, which possess a nonfunctional PTP1C gene, display multiple hematopoietic abnormalities including increased proliferation and activation of myeloid cells. Studies involving these mice have clearly implicated PTP1C in negative regulation of CSF-1 (colony stimulating factor-1) mitogenic signaling and have demonstrated a role for PTP1C as an intermediate between Ras and the MAP kinase pathway.

Host Species: Mouse
Clone: 52
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human PTP1C aa.. 492-597
Formula Weight [Chemical]: 68kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

PTP1C/SHP1
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
52
Western Blot
Unconjugated
RUO
Canine, Human, Mouse, Rat
Human PTP1C aa.. 492-597
Primary
Store undiluted at -20°C.
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