Securin Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA514240

Catalog No. PIPA514240

Description

PTTG1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The protein has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. This protein contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus.

Specifications

• Antigen: Securin
• Classification: Polyclonal
• Gene: PTTG1
• Gene Alias: Securin; Pituitary tumor-transforming gene 1 protein; hPTTG; Tumor-transforming protein 1; Esp1-associated protein; PTTG1; TUTR1; PTTG; EAP1; PTTG1
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 9232
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: O95997
• Gene Symbols: PTTG1
• Immunogen: KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human PTTG1
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG