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Securin Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA514240

Catalog No. PIPA514240

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

PTTG1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The protein has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. This protein contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus.
Specifications

Specifications

Securin
Polyclonal
PBS with 0.09% sodium azide
O95997
Securin; Pituitary tumor-transforming gene 1 protein; hPTTG; Tumor-transforming protein 1; Esp1-associated protein; PTTG1; TUTR1; PTTG; EAP1; PTTG1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9232
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Unconjugated
PTTG1
Liquid
PTTG1
KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human PTTG1
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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