PYCARD Goat anti-Human, Polyclonal, Invitrogen™
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA19010
DescriptionThis gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
|Synthetic peptide corresponding to the C terminus amino acids RESQSYLVEDLERS.|
|Antigen affinity chromatography|
|Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|PYCARD; PYD and CARD domain containing; ASC; CARD5; MGC10332; TMS1; apoptosis-associated speck-like protein containing a CARD; caspase recruitment dom|
|-20° C, Avoid Freeze/Thaw Cycles|
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