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RONα Mouse, Unlabeled, Clone: 29, BD

Mouse Monoclonal Antibody



Antigen RONα
Isotype IgG2b
Immunogen Human RONα aa. 40-224
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
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BD Biosciences
50μg Each for $207.00
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BD Biosciences
150μg This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


RON (Recepteur d ft. Origine Nantaise) is a tyrosine kinase receptor for MSP (Macrophage Stimulating Protein) that belongs to the hepatocyte growth factor receptor family. RON is synthesized as a single chain glycosylated polypeptide of 1400 amino acids that is cleaved upon maturation into a 150kDa β-subunit with the kinase activity and a 40kDa α-chain. Both chains are linked by disulfide bonds and the proper arrangement of the α and β heterodimer is necessary for biological activity of RON. MSP induces the tyrosine kinase activity of RON, triggering a cascade of intracellular signaling that leads to DNA synthesis. However, RON activation in mouse erythroleukemia cells results in apoptosis. The replacement of autophosphorylation sites Y1330 and Y1337 abolishes both the mitogenic and apoptotic effects of MSP. Therefore, autophosphorylation at Y1330 and Y1337 is required for RON's biological activity. PLCγ, Shc, Grb2, p61, and p65 associate with RON. Although widely expressed, RON is particularly abundant in epithelial tissues, lung, brain, adrenal glands, gastrointestinal tract, kidney and testis.

Immunofluorescence, Immunoprecipitation, Western Blotting



Human RONα aa. 40-224
Cell Biology
Affinity Purified
Recepteur d'Origine Nantaise
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Western Blot
Store undiluted at -20°C.

For Research Use Only.

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