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RONα Mouse, Unlabeled, Clone: 29, BD

Mouse Monoclonal Antibody

$207.00

Specifications

Antigen RONα
Isotype IgG2b
Immunogen Human RONα aa. 40-224
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610744
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BD Biosciences
610744
50μg Each for $207.00
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BDB610745
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BD Biosciences
610745
150μg This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

RON (Recepteur d ft. Origine Nantaise) is a tyrosine kinase receptor for MSP (Macrophage Stimulating Protein) that belongs to the hepatocyte growth factor receptor family. RON is synthesized as a single chain glycosylated polypeptide of 1400 amino acids that is cleaved upon maturation into a 150kDa β-subunit with the kinase activity and a 40kDa α-chain. Both chains are linked by disulfide bonds and the proper arrangement of the α and β heterodimer is necessary for biological activity of RON. MSP induces the tyrosine kinase activity of RON, triggering a cascade of intracellular signaling that leads to DNA synthesis. However, RON activation in mouse erythroleukemia cells results in apoptosis. The replacement of autophosphorylation sites Y1330 and Y1337 abolishes both the mitogenic and apoptotic effects of MSP. Therefore, autophosphorylation at Y1330 and Y1337 is required for RON's biological activity. PLCγ, Shc, Grb2, p61, and p65 associate with RON. Although widely expressed, RON is particularly abundant in epithelial tissues, lung, brain, adrenal glands, gastrointestinal tract, kidney and testis.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

RONα
Human RONα aa. 40-224
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Recepteur d'Origine Nantaise
IgG2b
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
29
250μg/mL
Store undiluted at -20°C.

For Research Use Only.

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