MilliporeSigma™ anti-TCR beta chain, FITC, Clone: H57-597,

Armenian Hamster Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
MABF1454MI	MilliporeSigma™ MABF1454	25 μg
MABF1455MI	MilliporeSigma™ MABF1455	100 μg

Description

Specifically detects TCR beta chain Clone: H57-597 in Mouse samples, and it is validated for Flow Cytometry

The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.

Specifications

• Antigen: TCR beta chain
• Applications: Flow Cytometry
• Conjugate: FITC
• Host Species: Armenian Hamster
• Research Discipline: Inflammation, Immunology
• Formulation: Purified Armenian Hamster monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
• Gene Symbols: Ptcra
• Isotype: IgG
• Purification Method: Purified by size-exclusion chromatography

• Clone: H57-597
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Mouse
• Gene Accession No.: P0C6B2
• Immunogen: Proprietary immunogen
• Primary or Secondary: Primary
• Content And Storage: 2°C to 8°C for one year from date of shipment protected from light; Do not freeze

For Research Use Only