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TEF-1 Mouse, Unlabeled, Clone: 31, BD
Mouse Monoclonal Antibody
$287.50 - $568.50
Specifications
Antigen | TEF-1 |
---|---|
Clone | 31 |
Concentration | 250μg/mL |
Applications | Western Blot |
Classification | Monoclonal |
Description
TEF-1 (transcription enhancer factor-1) is a member of a family of transcription factors that contain an evolutionarily conserved DNA binding domain (DBD), TEA/ATTS. TEF-1 was identified as a HeLa cell transcriptional activator that bound, via its TEA domain, to the GT-IIC and Sph enhancer elements. Comparison of various enhancers indicates that TEF-1 binds to highly degenerate DNA sequences and cooperatively interacts with tandem repeats of its binding sites, which increases its enhancer activity. However, the DNA binding activities of TEF-1 are modulated by sequences outside the DBD. The N-terminal basic portion of TEF-1 contains the DBD. The C-terminal portion contains the transactivation domain and a zinc finger-like motif that is thought to be involved in protein dimerization or interaction with additional transcription factors. TEF-1 induced transcription requires a limiting transcriptional intermediary factor (TIF) and a TATA-binding protein associated factor (hTAFIIs). Although TEF-1 is expressed ubiquitously during embryogenesis, its expression is limited to adult kidney, heart, brain, skeletal muscle, and lungs. Disruption of murine TEF-1 gene results in fetal death.
Immunofluorescence, Western Blotting
Specifications
TEF-1 | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 | |
Affinity Purified |
31 | |
Western Blot | |
Unconjugated | |
RUO | |
Human, Mouse | |
Human TEF-1 aa. 86-199 | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.
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