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TSG101 [Tumor Susceptibility Gene 101] Mouse, Unlabeled, Clone: 51, BD

Mouse Monoclonal Antibody

$287.50 - $566.00

Specifications

Antigen TSG101 [Tumor Susceptibility Gene 101]
Clone 51
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB612696
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BD Biosciences
612696
50 μg
Each for $287.50
Only null left
Add to Cart
 
BDB612697
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BD Biosciences
612697
150 μg
Each for $566.00
Only null left
Add to Cart
 
Description

Description

Tumor Susceptibility Gene 101 (TSG101) was identified in a random mutagenesis screen for potential tumor suppressors in NIH 3T3 cells. Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. Though the function of TSG101 is not clearly understood, its protein structure includes motifs involved in transcription regulation, and TSG101 has been shown to modulate the activation of steroid hormone receptors. In addition, TSG101 may have a role in regulating ubiquination. The N-terminal region of TSG101 contains a domain that resembles the catalytically active region of ubiquitin conjugases. However, TSG101 lacks an active-site cysteine crucial to the function of these conjugases. Interestingly, TSG101 interferes with MDM2 ubiquination leading to a decrease in MDM2 decay and down-regulation of p53 protein. Thus, TSG101 may function as a dominant-negative inhibitor of ubiquination in pathways where protein expression is tightly regulated.

Western Blotting

Specifications

Specifications

TSG101 [Tumor Susceptibility Gene 101]
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
Tumor Susceptibility Gene 101
51
Western Blot
Unconjugated
RUO
Canine, Human, Mouse, Rat
Human TSG101 aa. 229-319
Primary
Store undiluted at -20°C.
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