Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

TSG101 [Tumor Susceptibility Gene 101] Mouse, Unlabeled, Clone: 51, BD

Mouse Monoclonal Antibody

$232.00 - $458.00

Specifications

Antigen TSG101 [Tumor Susceptibility Gene 101]
Isotype IgG1
Immunogen Human TSG101 aa. 229-319
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB612696
View Documents
BD Biosciences
612696
50μg
Each for $232.00
Add to cart
 
BDB612697
View Documents
BD Biosciences
612697
150μg
Each for $458.00
Add to cart
 
Description

Description

Tumor Susceptibility Gene 101 (TSG101) was identified in a random mutagenesis screen for potential tumor suppressors in NIH 3T3 cells. Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. Though the function of TSG101 is not clearly understood, its protein structure includes motifs involved in transcription regulation, and TSG101 has been shown to modulate the activation of steroid hormone receptors. In addition, TSG101 may have a role in regulating ubiquination. The N-terminal region of TSG101 contains a domain that resembles the catalytically active region of ubiquitin conjugases. However, TSG101 lacks an active-site cysteine crucial to the function of these conjugases. Interestingly, TSG101 interferes with MDM2 ubiquination leading to a decrease in MDM2 decay and down-regulation of p53 protein. Thus, TSG101 may function as a dominant-negative inhibitor of ubiquination in pathways where protein expression is tightly regulated.

Western Blotting

Specifications

Specifications

TSG101 [Tumor Susceptibility Gene 101]
Human TSG101 aa. 229-319
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Tumor Susceptibility Gene 101
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
51
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit