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Invitrogen™ UNC5CL Monoclonal Antibody (3G7)
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Catalog No. PIMA523197
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100 μg
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PIMA523197 100 μg
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Catalog No. PIMA523197 Supplier Invitrogen™ Supplier No. MA523197
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Description

Mouse Monoclonal Antibody

Peptide Sequence: MCPQESSFQP SQFLLLVGVP VASVLLLAQC LRWHCPRRLL GACWTLNGQE EPVSQPTPQL ENEVSRQHLP ATLPEMVAFY QELHTPTQGQ TMVRQLMHKL LVFSAREVDH RGGCLMLQDT GISLLIPPGA VAVGRQERVS LILVWDLSDA PSLSQAQGLV SPVVACGPHG ASFLKPCTLT FKHCAEQPSH ARTYSSNTTL LDAKVWRPLG RPGAHASRDE CRIHLSHFSL YTCVLEAPVG REARKWLQLA VFCSPLVPGQ SHLQLRIYFL NNTPCALQWA LTNEQPHGGR LRGPCQLFDF NGARGDQCLK LTYISEGWEN VDDSSCQLVP HLHIWHGKCP FRSFCFRRKA ADENEDCSAL TNEIIVTMHT FQDGLETKYM EILRFQASEE ESWAAPPPVS QPPPCNRLPP ELFEQLRMLL EPNSITGNDW RGLASHLGLC GMKIRFLSCQ RSPAAAILEL FEEQNGSLQE LHYLMTVMER LDCASAIQNY LSGTHGGSPG PERGGARDNQ GLELDEKL.

UNC5CL is a membrane protein belonging to theUNC-5 family with a death domain and a ZU5 domain and is known to interact with p65/RELA and NFKB1. UNC5CL is known to interact with subunit p105 of NF-kappaB and transactivator p65 and is thus involved in inhibition of NF-kappaB activation and NF-kappaB-dependent transcription by inhibiting the binding of NF-kappaB to its target sequence (providing an alternative regulatory mechanism for NF-kappaB-mediated transcription). This regulatory protein sensitizes cells to apoptosis induced by TNF and TRAIL.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UNC5CL
Applications ELISA, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3G7
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene UNC5CL
Gene Accession No. Q8IV45
Gene Alias 2510009H09Rik; BB155270; MGC34763; MUXA; OTTHUMP00000016362; protein unc-5 homolog C-like; unc-5 family C-terminal like; unc-5 homolog C (C. elegans)-like; UNC5CL; UNC5C-like protein; zu-5; ZU5 and death domain containing; ZU5 and death domain-containing inhibitor of NF-kB; ZU5 and death domain-containing protein; ZUD
Gene Symbols UNC5CL
Host Species Mouse
Immunogen UNC5CL (AAH35284, 1 a.a. ~ 518 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 222643
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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