ANTXR1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-9971	Proteintech Group Inc 150911AP150UL	150 μL

Description

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Specifications

• Antigen: ANTXR1
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q0PMD2, Q9CZ52, Q9H6X2
• Gene ID (Entrez): 362393, 69538, 84168
• Immunogen: ANTXR1 Fusion Protein Ag4626
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: ANTXR1

• Concentration: 0.27 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: anthrax toxin receptor 1, ANTXR1, ATR, TEM8, Tumor endothelial marker 8
• Gene Symbols: Antxr1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody