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Invitrogen™ APAF1 Monoclonal Antibody (2E10)
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Catalog No. PIMA515743
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100 μg
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Catalog No. Quantity
PIMA515743 100 μg
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Catalog No. PIMA515743 Supplier Invitrogen™ Supplier No. MA515743
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Description

Mouse Monoclonal Antibody

In Western blot applications, this antibody detects a band at ~130kDa. A suggested positive control is K562 cell lysate.

APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APAF1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2E10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene APAF1
Gene Accession No. O14727, O88879, Q9EPV5
Gene Alias 6230400I06Rik; APAF1; APAF-1; Apaf1l; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; CED4; DKFZp781B1145; fog; forebrain overgrowth; KIAA0413; mKIAA0413
Gene Symbols APAF1
Host Species Mouse
Immunogen A peptide corresponding to amino acids near the carboxy terminus of human Apaf1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11783, 317, 78963
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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