APC2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-8835	Proteintech Group Inc 135591AP150UL	150 μL

Description

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.

Specifications

• Antigen: APC2
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q8BZQ7, Q9UJX6
• Gene ID (Entrez): 296558, 29882, 99152
• Immunogen: APC2 Fusion Protein Ag4427
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: ANAPC2

• Concentration: 0.15 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: ANAPC2, APC2, Cyclosome subunit 2, KIAA1406, RP11 350O14.5
• Gene Symbols: Anapc2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody