Invitrogen™ ARTS1 Recombinant Rabbit Monoclonal Antibody (6V8C0)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538154

Catalog No. PIMA538154

Description

Positive Samples: HepG2, Jurkat, Mouse lung, Mouse liver, Rat liver Immunogen sequence: NPVGYPLAWQ FLRKNWNKLV QKFELGSSSI AHMVMGTTNQ FSTRTRLEEV KGFFSSLKEN GSQLRCVQQT IETIEENIGW MDKNFDKIRV WLQSEKLERM.

The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is a 120 kDa protein localized to the lumen of the ER, which removes NH2-terminal residues from many antigenic precursors for MHC class I peptide presentation. Peptides that are presented by MHC class I on the surface of a cell must be 8-11 residues long, and ERAP1 specifically trims peptides of 9 amino acids or more. ERAP1 is also induced by interferon- gamma. The gene encoding human ERAP1 maps to chromosome 5q15. ERAP1 has previously been characterized as adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1). A-LAP is thought to inactivate several bioactive peptides, including angiotensin II and, subsequently, may be involved in the regulation of blood pressure. PILS-AP is described as playing a role in angiogenesis by regulating the proliferation and migration of endothelial cells, and ARTS-1 is characterized as a TNFR1 binding protein that promotes TNFR1 shedding. Further research will be necessary to fully elucidate the functions of this protein.

Specifications

• Antigen: ARTS1
• Classification: Recombinant Monoclonal
• Concentration: 1.08 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9EQH2, Q9JJ22, Q9NZ08
• Gene Symbols: Erap1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 842-941 of human ERAP1 (Q9NZ08).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 6V8C0
• Conjugate: Unconjugated
• Gene: Erap1
• Gene Alias: adipocyte-derived leucine aminopeptidase; ALAP; A-LAP; aminopeptidase PILS; aminopeptidase regulator of TNFR1 shedding; Appils; Arts1; ARTS-1; CTD-2260A17.2; endoplasmic reticulum aminopeptidase 1; endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-15 isoform; endoplasmic reticulum aminopeptidase associated with antigen processing; ERAAP; ERAAP1; ER-aminopeptidase 1; ERAP1; KIAA0525; leucyl-specific aminopeptidase PILS; PILSA; PILSAP; PILS-AP; Puromycin-insensitive leucyl-specific aminopeptidase; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator; UNQ584/PRO1154; VEGF-induced aminopeptidase
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51752, 80897, 80898
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov