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Tocris Bioscience™ AS 1842856

Potent and selective Foxo1 inhibitor; orally bioavailable

$99.80 - $419.00


CAS 836620-48-5
Chemical Name or Material 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Molecular Formula C18H22FN3O3
Purity 98%
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Tocris Bioscience™
10 mg
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Tocris Bioscience™
50 mg
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  • Potent and selective Foxo1 inhibitor (IC50 values are 33 nM at Foxo1 and >1 μM at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by 70%, 20% and 3% at Foxo1, Foxo4 and Foxo3, respectively.
  • Regulates gluconeogenesis both in vitro and in vivo.
  • Attenuates fasting plasma glucose level in diabetic db/db mice.
  • Also suppresses autophagy, adipocyte differentiation and soluble guanylyl cyclase expression.
  • Also inhibits STAT3 signaling in NSCLC.
  • Orally bioavailable.


5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
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