ASAP2 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-156-4812	Bethyl Laboratories, Inc A303311AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt.

ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. This protein localizes in the Golgi apparatus and also at the plasma membrane where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2. It functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. ASAP2 activates the small GTPases ARF1, ARF5 and ARF6 and regulates the formation of post-Golgi vesicles and modulates constitutive secretion. It modulates phagocytosis mediated by Fc gamma receptor and ARF6. Usually detected in heart, brain, placenta, kidney, monocytes and pancreas, it is up-regulated during monocyte maturation. Multiple transcript variants encoding different isoforms have been found.

Specifications

• Antigen: ASAP2
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: AMAP2, centaurin, beta 3, CENTB3, DDEF2, development and differentiation enhancing factor 2, development and differentiation-enhancing factor 2, KIAA0400, PAG3, PAP, Pap-alpha, paxillin-associated protein with ARF GAP activity 3, PYK2 C terminus-associated protein, pyk2 C-terminus-associated protein, SHAG1
• Gene Symbols: ASAP2
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody

• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: O43150
• Gene ID (Entrez): 8853
• Immunogen: Between 900 and 950
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: ASAP2