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Atezolizumab Mouse, Clone: 6B12, GenScript™

Catalog No. 502120671
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40 μg
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Catalog No. Quantity
50-212-0671 40 μg
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Catalog No. 50-212-0671 Supplier Genscript Corporation Supplier No. A0194940
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Description

Mouse Monoclonal Antibody

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL. Atezolizumab is a fully humanized, engineered monoclonal antibody of IgG1 isotype against the protein programmed cell death-ligand 1 (PD-L1). Atezolizumab blocks the interaction of PD-L1 with programmed cell death protein 1 (PD-1) and CD80 receptors (B7-1Rs). PD-L1 can be highly expressed on certain tumors, which is thought to lead to reduced activation of immune cells (cytotoxic T-cells in particular) that might otherwise recognize and attack the cancer. Inhibition of PD-L1 by atezolizumab can remove this inhibitor effect and thereby engender an anti-tumor response. It is one of several ways to block inhibitory signals related to T-cell activation, a more general strategy known as immune checkpoint inhibition.

Atezolizumab Monoclonal antibody specifically detects Atezolizumab in Chemical samples. It is validated for ELISA

Specifications

Antigen Atezolizumab
Applications ELISA
Classification Monoclonal
Clone 6B12
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide; pH 7.4
Gene Alias Tecentriq
Host Species Mouse
Immunogen Atezolizumab
Purification Method Protein A
Quantity 40 μg
Regulatory Status RUO
Primary or Secondary Primary
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Lyophilized
Isotype IgG1 κ
Target Molecule Chemical
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