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Aurora Kinase BRabbit anti-Human, Polyclonal, Rockland™
SDP

Catalog No. 501991760
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Catalog No. Quantity
50-199-1760 100 μg
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Catalog No. 50-199-1760 Supplier Rockland Immunochemicals Supplier No. 600401465
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Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Reactivity occurs against human Aurora Kinase B protein. No reaction is expected against Aurora Kinase A. However, 100% sequence homology as indicated by BLAST analysis is on record for this protein from human, mouse, rat, cow, pig, dog and chimpanzee. Cross reactivity with Aurora Kinase B from other sources is not known.

Aurora-B kinase (AurB) is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples. Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.

Specifications

Antigen Aurora Kinase B
Applications ELISA, Immunofluorescence, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1.39 mg/mL
Conjugate Unconjugated
Formulation 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene AURKB
Gene Accession No. Q96GD4
Gene Alias AIE2; AIK1; Aik2; AIK3; AIM1; AIM-1; AIRK2; AIRK3; AL022959; Ark2; ARK-2; ARK3; ARK-3; AurB; Aurkb; aurkb-sv1; aurkb-sv2; AURKC; Aurora 1; Aurora 3; Aurora- and IPL1-like midbody-associated protein 1; aurora B; Aurora kinase B; aurora kinase B; serine/threonine-protein kinase 12; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora kinase C; Aurora/IPL1-related kinase 2; aurora-1; aurora-B; aurora-related kinase 2; BOS_18918; EC 2.7.11.1; IPL1; NP_004208; PPP1R48; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B; STK1; STK-1; STK12; STK13; STK5
Gene Symbols AURKB
Host Species Rabbit
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9212
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
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