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Axitinib, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
Axitinib is a potent inhibitor of VEGFR-2, -3, and -1 (IC50 values are 0.2, 0.1-0.3, and 1.2 nM respectively). Axitinib exhibits minimal activity against a panel of ∼100 protein kinases. Axitinib inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibitor (Ki = 149 pM for autophosphorylated ABL1 (T315I)). Axitinib blocks proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Axitinib (10 mg/kg) decreases T-cell exhaustion and tumor and T-cell hypoxia and improves survival in mice in vivo. Orally available.
Specifications
Quantity | 50 mg |
Formula Weight | 386.47 |
Percent Purity | >99% |
Chemical Name or Material | Axitinib |
Safety and Handling
Recommended Storage | Store at +4°C |
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