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  5. Tocris Bioscience™ Axitinib

Tocris Bioscience™ Axitinib
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Catalog No. 435010
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Quantity:
10 mg
50 mg
Catalog No. Quantity
43-501-0 10 mg
43-505-0 50 mg
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Catalog No. 43-501-0

Supplier: Tocris Bioscience™ 4350/10

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Description

Potent VEGFR-1, -2 and -3 inhibitor

Axitinib is a potent inhibitor of VEGFR-2, -3, and -1 (IC50 values are 0.2, 0.1-0.3, and 1.2 nM respectively). Axitinib exhibits minimal activity against a panel of ∼100 protein kinases. Axitinib inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibitor (Ki = 149 pM for autophosphorylated ABL1 (T315I)). Axitinib blocks proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Axitinib (10 mg/kg) decreases T-cell exhaustion and tumor and T-cell hypoxia and improves survival in mice in vivo. Orally available.

Chemical Identifiers

CAS 319460-85-0
Molecular Formula C22H18N4OS

Specifications

Quantity 10 mg
Formula Weight 386.47
Purity >99%
Molecular Weight (g/mol) 386.473
Chemical Name or Material Axitinib

Safety and Handling

Recommended Storage Store at +4°C
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