Tocris™ AZ 20

Potent and selective ATR kinase inhibitor; antitumor

Manufacturer: Tocris™ 5198/10

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Catalog No. 51-981-0

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For Research Use Only


    Inhibitors AZ 20
    Purity >98
    Molecular Weight 412.51
    Quantity 10mg
    Product Type AZ 20

    Potent and selective ATR kinase inhibitor (IC50 = 5nM). Exhibits 7.6-fold selectivity over mTOR and selectivity over a panel of 442 kinases, including ATM kinase, PI3-K isoforms, and DNA-PK. Inhibits cell growth in cell lines with high baseline levels of replication stress. Displays antitumor effects in vivo.

    • Chemical Name: 4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole
    • Formula: C21H24N4O3S
    • CAS Number: 1233339-22-4
    • Solubility: Soluble to 50mM in DMSO and to 10mM in ethanol
    • Purity: >98

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