Tocris AZ 20
Potent and selective ATR kinase inhibitor; antitumor
Manufacturer: Tocris 5198/10
DescriptionPotent and selective ATR kinase inhibitor (IC50 = 5nM). Exhibits 7.6-fold selectivity over mTOR and selectivity over a panel of 442 kinases, including ATM kinase, PI3-K isoforms, and DNA-PK. Inhibits cell growth in cell lines with high baseline levels of replication stress. Displays antitumor effects in vivo.
- Chemical Name: 4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole
- Formula: C21H24N4O3S
- CAS Number: 1233339-22-4
- Solubility: Soluble to 50mM in DMSO and to 10mM in ethanol
- Purity: >98
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