Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Benzenoids
  6. Benzene and substituted derivatives
  7. Phenylpropanes
  8. AZ 628, Tocris Bioscience™

AZ 628, Tocris Bioscience™

Catalog Number p-4816906
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
878739-06-1
C27H25N5O2
451.53
MFCD17392577
ZGBGPEDJXCYQPH-UHFFFAOYSA-N
3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl amino phenyl benzamide, 3-1-cyano-1-methylethyl-n-3-3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl amino-4-methylphenyl benzamide, 3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino phenyl benzamide, 3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxoquinazolin-6-yl amino phenyl benzamide, 3-1-cyano-1-methylethyl-n-4-methyl-3-3-methyl-4-oxoquinazolin-6-yl amino phenyl benzamide, b1e, benzamide, 3-1-cyano-1-methylethyl-n-3-3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl amino-4-methylphenyl, 3-1-cyano-1-methylethyl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl amino phenyl benzamide
11676786
3-(1-cyano-1-methylethyl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide
CN1C=NC2=CC=C(NC3=C(C)C=CC(NC(=O)C4=CC(=CC=C4)C(C)(C)C#N)=C3)C=C2C1=O
This item is not returnable. View return policy
878739-06-1
C27H25N5O2
451.53
MFCD17392577
ZGBGPEDJXCYQPH-UHFFFAOYSA-N
3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl amino phenyl benzamide, 3-1-cyano-1-methylethyl-n-3-3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl amino-4-methylphenyl benzamide, 3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino phenyl benzamide, 3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxoquinazolin-6-yl amino phenyl benzamide, 3-1-cyano-1-methylethyl-n-4-methyl-3-3-methyl-4-oxoquinazolin-6-yl amino phenyl benzamide, b1e, benzamide, 3-1-cyano-1-methylethyl-n-3-3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl amino-4-methylphenyl, 3-1-cyano-1-methylethyl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl amino phenyl benzamide
11676786
3-(1-cyano-1-methylethyl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide
CN1C=NC2=CC=C(NC3=C(C)C=CC(NC(=O)C4=CC(=CC=C4)C(C)(C)C#N)=C3)C=C2C1=O

Description

Potent Raf kinase inhibitor

Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
Quantity 10 mg
Formula Weight 451.52
Percent Purity >98%
Chemical Name or Material AZ 628

Safety and Handling

Recommended Storage Store at +4°C
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit