Tocris™ AZD 5582 dihydrochloride

Dimeric Smac mimetic; potent IAP inhibitor

Manufacturer: Tocris™ 5141/50

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Catalog No. 51-415-0

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For Research Use Only


    Product Type AZD 5582 dihydrochloride
    Inhibitors AZD 5582 dihydrochloride
    Purity >97
    Molecular Weight 1088.21
    Quantity 50mg

    Dimeric Smac mimetic; Potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.

    • Chemical Name: 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide
    • Formula: C58H78N8O8.2HCl
    • Solubility: Soluble to 100mM in water and to 100mM in DMSO
    • Purity: >97

  • Description & Specifications

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