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B220/CD45R Antibody (PTPRC/1460), Alexa Fluor™ 350, Novus Biologicals™
SDP

Catalog No. NP2446A30 Shop All R&D Systems Products
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NP2446A30 0.1 mL
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Catalog No. NP2446A30 Supplier Novus Biologicals Supplier No. NBP254465AF350
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Description

Mouse Monoclonal Antibody

B220/CD45R Monoclonal specifically detects B220/CD45R in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen B220/CD45R
Applications Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone PTPRC/1460
Conjugate Alexa Fluor 350
Dilution Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias B220, CD45 antigen, CD45R, EC 3.1.3.48, L-CA, LY5, protein tyrosine phosphatase, receptor type, C, receptor-type tyrosine-protein phosphatase C, T200 glycoprotein, T200 leukocyte common antigen, T200receptor type, c polypeptide
Gene Symbols PTPRC
Host Species Mouse
Immunogen Human B-lymphocytes (Uniprot: P08575)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Adaptive Immunity, Cell Biology, Cellular Markers, Cellular Signaling, Cytokine Research, Glia Markers, Hematopoietic Stem Cell Markers, Immunology, Immunophenotyping, MAP Kinase Signaling, Mast Cell Markers, Mesenchymal Stem Cell Markers, Microglia Markers, Modulation of DNA Pools, Myeloid Cell Markers, Myeloid derived Suppressor Cell, Neurodegeneration, Neuronal Cell Markers, Neuroscience, Signal Transduction, Stem Cell Markers
Primary or Secondary Primary
Gene ID (Entrez) 5788.0
Test Specificity CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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