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B7-2/CD86 Antibody (C86/1146), Novus Biologicals™
SDP

Catalog No. NBP24451400 Shop All R&D Systems Products
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NBP24451400 0.02 mg
NBP24451401 0.1 mg
NBP24451402 0.2 mg
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Catalog No. NBP24451400 Supplier Novus Biologicals Supplier No. NBP2445140.02MG
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Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

B7-2/CD86 Monoclonal specifically detects B7-2/CD86 in Human, Mouse, Rat samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Knockout Validated.

Specifications

Antigen B7-2/CD86
Applications Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, KnockDown
Classification Monoclonal
Clone C86/1146
Concentration 0.2 mg/mL
Conjugate Unconjugated
Dilution Western Blot 0.5 - 1.0 ug/ml, Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 2 - 4 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml, Knockout Validated
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Accession No. P42081
Gene Alias Activation B7-2 antigen, B70, B7-2, B7-2 antigen, B-lymphocyte activation antigen B7-2, BU63, CD28 antigen ligand 2, CD28LG2B7-2 antigen), CD86 antigen, CD86 molecule, CTLA-4 counter-receptor B7.2, FUN-1, LAB72, MGC34413, T-lymphocyte activation antigen CD86
Gene Symbols CD86
Host Species Mouse
Immunogen Recombinant human full-length CD86 protein
Molecular Weight of Antigen 70 kDa
Purification Method Protein A or G purified
Quantity 0.02 mg
Regulatory Status RUO
Research Discipline Adaptive Immunity, Cell Cycle and Replication, Dendritic Cell Markers, Diabetes Research, Immunology
Primary or Secondary Primary
Gene ID (Entrez) 942
Test Specificity Recognizes a protein of 70kDa, which is identified as CD86. CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease.
Target Species Human, Mouse, Rat
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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