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Invitrogen™ B7-H3 Polyclonal Antibody
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Catalog No. PIPA582384
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PIPA582384 100 μL
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Catalog No. PIPA582384 Supplier Invitrogen™ Supplier No. PA582384
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YSKPSMTLEP NKDLRPGDTV TITCSSYRGY PEAEVFWQDG QGVPLTGNVT TSQMANEQGL FDVHSVLRVV LGANGTYSCL VRNPVLQQDA HGSVTITGQP Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 95%.

CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen B7-H3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CD276
Gene Accession No. Q5ZPR3
Gene Alias 4Ig-B7-H3; 6030411F23Rik; AU016588; B7 homolog 3; B7h3; B7-H3; B7RP-2; CD276; CD276 antigen; CD276 molecule; CD276 molecule tv1; costimulatory molecule; PSEC0249; sB7 H3; sB7H3; sCD276; soluble B7 H3; soluble B7H3; soluble CD276; UNQ309/PRO352
Gene Symbols CD276
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CD276. Recombinant protein control fragment (Product #RP-90038).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80381
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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