MilliporeSigma™ BAG6 (BAT3), Rabbit, Unlabeled, Polyclonal,

Catalog No.	Quantity	Conjugate
ABC1437MI	100 μL	Unconjugated

Catalog No. ABC1437MI Supplier MilliporeSigma™ Supplier No. ABC1437

Description

Rabbit Polyclonal Antibody

Large proline-rich protein BAG6 (UniProt P46379 ; also known as BAG family molecular chaperone regulator 6, BAG-6, BAG6, BCL2-associated athanogene 6, HLA-B-associated transcript 3, Protein G3, Protein Scythe) is encoded by the BAG6 (also known as BAT3, G3) gene (Gene ID 7917) in human. BAG6 is a chaperone that plays a key role in various cellular processes, including apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane, and regulation of chromatin. BAG6 is a key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of TA membrane proteins to the endoplasmic reticulum membrane. BAG6/BAT3 complex also regulates the stability and the degradation of proteins by the proteasome and may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. It also plays a role in ubiquitin-mediated proteasomal degradation of proteins of the secretory pathway that are mislocalized to the cytosol. In this regard it binds the mislocalized proteins and promotes their ubiquitination and degradation, thereby prevents their aggregation in the cytosol. It is also involved in DNA damage-induced apoptosis. Following DNA damage, it accumulates in the nucleus and forms a complex with p300/EP300 and enhances p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity.

Specifications

• Antigen: BAG6 (BAT3)
• Applications: Immunofluorescence, Western Blot
• Classification: Polyclonal
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Unconjugated
• Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
• Gene: BAG6, BAT3, G3
• Gene Accession No.: P46379
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding a C-terminal region sequence of human BAG6.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Apoptosis & Cancer
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_004630
• Test Specificity: ABC1437 corresponds to the rabbit antiserum raised against the Scythe 23 peptide, but not the serum against Scythe 25 peptide by Desmots, F., et al. (2005. Mol. Cell. Biol. 25(23):10329-10337). This antiserum targets a C-terminal region sequence conserved among human, mouse, and rat BAG6 (BAT3).
• Target Species: Human
• Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
• Form: Serum

For Research Use Only. Not for use in diagnostic procedures.