BBS9 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-9467	Proteintech Group Inc 144601AP150UL	150 μL

Description

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.

Specifications

• Antigen: BBS9
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: Q3SYG4, Q811G0
• Gene ID (Entrez): 27241, 319845
• Immunogen: BBS9 Fusion Protein Ag5665
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: BBS9

• Concentration: 0.37 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: B1, Bardet Biedl syndrome 9, BBS9, C18, D1, Protein PTHB1, PTHB1
• Gene Symbols: BBS9
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody