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Bcl-2 Antibody (BCL2/782 + BCL2/796), Alexa Fluor™ 700, Novus Biologicals™
SDP

Catalog No. NB247853700 Shop All R&D Systems Products
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NB247853700 0.1 mL
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Catalog No. NB247853700 Supplier Novus Biologicals Supplier No. NBP247853AF700
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Description

Mouse Monoclonal Antibody

Bcl-2 Monoclonal specifically detects Bcl-2 in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Bcl-2
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone BCL2/782 + BCL2/796
Conjugate Alexa Fluor 700
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, Bcl-2
Gene Symbols BCL2
Host Species Mouse
Immunogen Recombinant full-length human bcl-2 protein (Uniprot: P10415)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Apoptosis, Autophagy, Biologically Active Proteins, Cancer, Cellular Markers, Mitochondrial Mediated Pathway, Mitophagy, Oncogenes, Phospho Specific, Tumor Suppressors
Primary or Secondary Primary
Gene ID (Entrez) 596
Test Specificity This antibody recognizes a protein of 25-26kDa, identified as the Bcl-2 lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of Bcl-2 lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2 lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express Bcl-2 protein and the small number in which the neoplastic cells are Bcl-2 negative.
Target Species Human
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG1 κ
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