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  6. Bcl-6 Mouse anti-Human, Clone: BCL6/1475, Novus Biologicals™

Bcl-6 Mouse anti-Human, Clone: BCL6/1475, Novus Biologicals™
SDP

Catalog No. NBP25959620 Shop All R&D Systems Products
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NBP25959620 20 μg
NBP259596X 100 μg
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Catalog No. NBP25959620 Supplier Novus Biologicals Supplier No. NBP25959620UG
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Description

Mouse Monoclonal Antibody

Bcl-6 Monoclonal specifically detects Bcl-6 in Human samples. It is validated for Western Blot, Flow Cytometry, Protein Array.

Specifications

Antigen Bcl-6
Applications Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, SDS-Page
Classification Monoclonal
Clone BCL6/1475
Concentration 0.2 mg/mL
Conjugate Unconjugated
Dilution Western Blot 0.5-1 ug/ml, Flow Cytometry 0.5-1 ug/million cells, Immunocytochemistry/Immunofluorescence 1-2 ug/ml, SDS-Page, Protein Array 1:100-1:2000
Formulation 10mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene Alias B-cell CLL/lymphoma 6, B-cell lymphoma 6 protein transcript, BCL-5, BCL5B-cell lymphoma 5 protein, BCL-6, BCL6A, cys-his2 zinc finger transcription factor, LAZ3ZBTB27B-cell lymphoma 6 protein, lymphoma-associated zinc finger gene on chromosome 3, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51ZNF51, zinc finger transcription factor BCL6S
Gene Symbols BCL6
Host Species Mouse
Immunogen Recombinant human bcl-6 protein fragment (aa256-389)
Molecular Weight of Antigen 95 kDa
Purification Method Protein A or G purified
Quantity 20 μg
Regulatory Status RUO
Research Discipline Cancer, Cell Cycle and Replication, Tumor Suppressors
Primary or Secondary Primary
Gene ID (Entrez) 604
Test Specificity The specificity of this monoclonal antibody to its intended target was validated by HuProt(TM) Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma
Target Species Human
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1 κ
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