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Bcl-xL Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501557289
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50-155-7289 20 μL
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Catalog No. 50-155-7289 Supplier Bethyl Laboratories, Inc Supplier No. A300284AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat and Pig

Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3-dependent cell line, and Bax also counters the death repressor activity of Bcl-2. Bcl-x, one of several additional proteins with sequence homology to Bcl-2, is expressed as Bcl-xL, a 233 amino acid protein with 43% sequence identity with Bcl-2 that suppresses cell death, and Bcl-xS, a shorter variant that is 178 amino acids in length and lacks a 63 amino acid region (amino acids 126-188) found in Bcl-xL and which functions as a domit inhibitor of Bcl-2. A further apoptosis-inducing protein, Bad, dimerizes both with Bcl-xL and to a lesser extent with Bcl-2, thus displacing Bax and inducing apoptosis.

Specifications

Antigen Bcl-xL
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene BCL2L1
Gene Accession No. Q07817
Gene Alias BCL-XL/S, BCL2L, BCLX, Bcl-X, DKFZp781P2092, bcl-2 L1, bcl-xS
Gene Symbols BCL2L1
Host Species Rabbit
Immunogen Between 1 and 50
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 598
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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