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Bcl-XL Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 107831AP150UL

Encompass_Preferred

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Catalog No. 50-172-6594


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Description

Description

This antibody can recognize Bcl-XL, Bcl-X (s) and Bcl-X(Beta).

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
Specifications

Specifications

Bcl-XL
Polyclonal
Unconjugated
BCL2L1
Apoptosis regulator Bcl X, BCL2L1, Bcl-XL
Rabbit
Antigen Affinity Chromatography
RUO
12048, 24888, 598
-20°C
Liquid
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
0.23 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P53563, Q07817, Q64373
BCL2L1
Bcl-XL Fusion Protein Ag1232
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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