Bcl-XL Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-6594	Proteintech Group Inc 107831AP150UL	150 μL

Description

This antibody can recognize Bcl-XL, Bcl-X (s) and Bcl-X(Beta).

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

Specifications

• Antigen: Bcl-XL
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P53563, Q07817, Q64373
• Gene ID (Entrez): 12048, 24888, 598
• Immunogen: Bcl-XL Fusion Protein Ag1232
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: BCL2L1

• Concentration: 0.23 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: Apoptosis regulator Bcl X, BCL2L1, Bcl-XL
• Gene Symbols: BCL2L1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody