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Invitrogen™ BDNF Monoclonal Antibody (C3), Invitrogen™
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Catalog No. FEMA550903
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200 μL
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FEMA550903 200 μL
FEMA550904 20 μL
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Catalog No. FEMA550903 Supplier Invitrogen™ Supplier No. MA550903
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Description

Mouse Monoclonal Antibody

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BDNF
Applications Western Blot, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone C3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
Gene BDNF
Gene Accession No. P14082, P23363
Gene Alias abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF
Gene Symbols BDNF
Host Species Mouse
Immunogen Recombinant Pig BDNF protein, Pro20-Arg252 (Accession #P14082).
Purification Method Protein A/G
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24225, 397495
Target Species Pig, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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