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beta 2-Microglobulin Antibody (B2M/961) - Azide and BSA Free, Novus Biologicals™

Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP2477040.2MG
Description
beta 2-Microglobulin Monoclonal antibody specifically detects Antigen in Human, Primate samples. It is validated for Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin).Specifications
beta 2-Microglobulin | |
Monoclonal | |
1.0 mg/mL | |
Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin : 0.5 - 1.0 ug/ml, Flow (Cell Surface) 1:10-1:1000, Immunofluorescence : 0.5 - 1.0 ug/ml, CyTOF-ready | |
beta chain of MHC class I molecules, beta-2-microglobin, beta-2-microglobulin | |
Mouse | |
12 kDa | |
0.2 mg | |
Adaptive Immunity, Cancer, Cell Biology, Diabetes Research, Immunology | |
567 | |
Human, Primate | |
Purified |
Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF | |
B2M/961 | |
Unconjugated | |
PBS with No Preservative | |
B2M | |
Full length recombinant human B2M protein | |
Protein A or G purified | |
RUO | |
Primary | |
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes. | |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | |
IgG2b κ |
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