beta 2-Microglobulin Antibody (B2M/961), Novus Biologicals™

Catalog No.	Quantity
NBP24447100	0.02 mg
NBP24447101	0.1 mg
NBP24447102	0.2 mg

Catalog No. NBP24447100 Supplier Novus Biologicals Supplier No. NBP2444710.02MG

Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

beta 2-Microglobulin Monoclonal specifically detects beta 2-Microglobulin in Human, Primate samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Flow (Cell Surface).

Specifications

• Antigen: beta 2-Microglobulin
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
• Classification: Monoclonal
• Clone: B2M/961
• Concentration: 0.2mg/mL
• Conjugate: Unconjugated
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Accession No.: P61769
• Gene Alias: beta chain of MHC class I molecules, beta-2-microglobin, beta-2-microglobulin
• Gene Symbols: B2M
• Host Species: Mouse
• Immunogen: Full length recombinant human B2M protein
• Molecular Weight of Antigen: 12 kDa
• Purification Method: Protein A or G purified
• Quantity: 0.02 mg
• Regulatory Status: RUO
• Research Discipline: Adaptive Immunity, Cancer, Cell Biology, Diabetes Research, Immunology
• Primary or Secondary: Primary
• Gene ID (Entrez): 567
• Test Specificity: Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
• Target Species: Human, Primate
• Content And Storage: Store at 4C.
• Form: Purified
• Isotype: IgG2b κ

For Research Use Only