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beta 2-Microglobulin Antibody (SPM617) - IHC-Prediluted, Novus Biologicals™
SDP

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP248328

Catalog No. NBP248328


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Description

Description

beta 2-Microglobulin Monoclonal specifically detects beta 2-Microglobulin in Human, Primate samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
Specifications

Specifications

beta 2-Microglobulin
Monoclonal
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
B2M
Full length recombinant human beta 2-Microglobulin protein (Uniprot: P61769)
Protein A or G purified
RUO
Primary
Beta2 microglobulin is a 12KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy)
Store at 4C.
IgG1 κ
Immunohistochemistry (Paraffin)
SPM617
Immunohistochemistry-Paraffin
beta chain of MHC class I molecules, beta-2-microglobin, beta-2-microglobulin
Mouse
12 kDa
7 mL
Adaptive Immunity, Cancer, Cell Biology, Diabetes Research, Immunology
567
Human, Primate
Purified
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