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beta-Catenin Antibody (6F9), Alexa Fluor™ 750, Novus Biologicals™
SDP

Catalog No. NP2443A70 Shop All R&D Systems Products
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NP2443A70 0.1 mL
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Catalog No. NP2443A70 Supplier Novus Biologicals Supplier No. NBP254543AF750
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Description

Mouse Monoclonal Antibody

beta-Catenin Monoclonal specifically detects beta-Catenin in Human, Bovine, Canine, Chicken samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen beta-Catenin
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 6F9
Conjugate Alexa Fluor 750
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias beta 1 (88kD), beta-catenin, catenin (cadherin-associated protein), beta 1, 88kDa, catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923
Gene Symbols CTNNB1
Host Species Mouse
Immunogen Recombinant chicken beta-Catenin (Uniprot: P35222)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cancer, Cellular Markers, Cytoskeleton Markers, Extracellular Matrix, Immune System Diseases, Mucosal Immunology, Neuroscience, Phospho Specific, Signal Transduction, Stem Cell Signaling Pathway, Wnt Signaling Pathway
Primary or Secondary Primary
Gene ID (Entrez) 1499.0
Test Specificity This monoclonal antibody recognizes a protein of 92kDa, which is identified as beta-catenin. It shows no cross-reaction with gamma-catenin (also known as plakoglobin). The catenins, alpha, beta and gamma bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. Alpha-catenin was initially described as an E-cadherin-associated protein, and has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. Beta-catenin has also been found in complexes with the tumor suppressor protein APC.
Target Species Human, Bovine, Canine, Chicken
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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