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beta-Catenin Antibody (9F2), DyLight 594, Novus Biologicals™
SDP

Catalog No. NB008303 Shop All R&D Systems Products
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NB008303 0.1 mL
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Catalog No. NB008303 Supplier Novus Biologicals Supplier No. NBP254495DL594
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Description

Mouse Monoclonal Antibody

beta-Catenin Monoclonal specifically detects beta-Catenin in Human, Bovine, Canine, Chicken samples. It is validated for Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence.

Specifications

Antigen beta-Catenin
Applications Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence
Classification Monoclonal
Clone 9F2
Conjugate DyLight 594
Dilution Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias beta 1 (88kD), beta-catenin, catenin (cadherin-associated protein), beta 1, 88kDa, catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923
Gene Symbols CTNNB1
Host Species Mouse
Immunogen Recombinant chicken beta-Catenin (Uniprot: P35222)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Cancer, Cell Biology, Cellular Markers, Extracellular Matrix, Immune System Diseases, Mucosal Immunology, Neuroscience, Phospho Specific, Signal Transduction, Stem Cell Signaling Pathway, Wnt Signaling Pathway
Primary or Secondary Primary
Test Specificity This monoclonal antibody recognizes a protein of 92kDa, which is identified as beta-catenin. It shows no cross-reaction with gamma-catenin (also known as plakoglobin). The catenins, alpha, beta and gamma bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. Alpha-catenin was initially described as an E-cadherin-associated protein, and has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. Beta-catenin has also been found in complexes with the tumor suppressor protein APC.
Target Species Human, Bovine, Canine, Chicken
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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