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beta-Catenin, Rabbit anti-Human,Mouse, Alexa Fluor 750, Polyclonal, Novus Biologicals™
SDP

Catalog No. NB005665 Shop All R&D Systems Products
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NB005665 0.1 mL
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Catalog No. NB005665 Supplier Novus Biologicals Supplier No. NBP233124AF750

Description

Rabbit Polyclonal Antibody

beta-Catenin Polyclonal specifically detects beta-Catenin in Human, Mouse samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen beta-Catenin
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Alexa Fluor 750
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias beta 1 (88kD), beta-catenin, catenin (cadherin-associated protein), beta 1, 88kDa, catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923
Gene Symbols CTNNB1
Host Species Rabbit
Immunogen A synthetic peptide from the middle of beta-Catenin protein
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Cancer, Cell Biology, Cellular Markers, Extracellular Matrix, Immune System Diseases, Mucosal Immunology, Neuroscience, Phospho Specific, Signal Transduction, Stem Cell Signaling Pathway, Wnt Signaling Pathway
Primary or Secondary Primary
Test Specificity Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
Target Species Human, Mouse
Content And Storage Store at 4°C in the dark.
Isotype IgG
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